The Relationship Between Cognition and Cerebrovascular Reactivity: Implications for Task-Based fMRI

Elucidating the brain regions and networks associated with cognitive processes has been mainstay of task-based fMRI, under assumption that BOLD signals are uncompromised by vascular function. This is despite plethora research highlighting modulations due to changes induced disease, drugs, aging. On other hand, fMRI-based assessment cerebrovascular reactivity (CVR) often used as an indicator brain's health shown be strongly review paper considers relationship between BOLD-based assessments CVR, cognition fMRI. How response reflects both CVR neural activity, how findings altered in disease normal physiology signal discussed. These pertinent considerations for fMRI applications aiming understand biological basis cognition. Therefore, a discussion acquisition can enhance our ability map human function, limitations potential future directions, presented.